Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model

IMPORTANCE: Neuroinflammation appears to be a key modulator of disease progression in amyotrophic lateral sclerosis (ALS) and thereby a promising therapeutic target. The CD4(+)Foxp3(+) regulatory T-cells (Tregs) infiltrating into the central nervous system suppress neuroinflammation and promote the...

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Bibliografiska uppgifter
I publikationen:JAMA Neurol
Huvudupphovsmän: Sheean, Rebecca K., McKay, Fiona C., Cretney, Erika, Bye, Christopher R., Perera, Nirma D., Tomas, Doris, Weston, Richard A., Scheller, Karlene J., Djouma, Elvan, Menon, Parvathi, Schibeci, Stephen D., Marmash, Najwa, Yerbury, Justin J., Nutt, Stephen L., Booth, David R., Stewart, Graeme J., Kiernan, Mathew C., Vucic, Steve, Turner, Bradley J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Medical Association 2018
Ämnen:
Original Investigation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5885208/
https://ncbi.nlm.nih.gov/pubmed/29507931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2018.0035
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