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Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats
AIM: To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS: CIA rat models were immunized with bovine type II collagen. Serum IL-6 l...
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| Izdano u: | Z Rheumatol |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer Medizin
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5884908/ https://ncbi.nlm.nih.gov/pubmed/27900440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00393-016-0236-6 |
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