CEBPE-Mutant Specific Granule Deficiency Correlates With Aberrant Granule Organization and Substantial Proteome Alterations in Neutrophils

Specific granule deficiency (SGD) is a rare disorder characterized by abnormal neutrophils evidenced by reduced granules, absence of granule proteins, and atypical bilobed nuclei. Mutations in CCAAT/enhancer-binding protein-ε (CEBPE) are one molecular etiology of the disease. Although C/EBPε has bee...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Serwas, Nina K., Huemer, Jakob, Dieckmann, Régis, Mejstrikova, Ester, Garncarz, Wojciech, Litzman, Jiri, Hoeger, Birgit, Zapletal, Ondrej, Janda, Ales, Bennett, Keiryn L., Kain, Renate, Kerjaschky, Dontscho, Boztug, Kaan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884887/
https://ncbi.nlm.nih.gov/pubmed/29651288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00588
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