Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure

During acute-phase response (APR), there is a dramatic increase in serum amyloid A (SAA) in plasma high density lipoproteins (HDL). Elevated SAA leads to reactive AA amyloidosis in animals and humans. Herein, we employed apolipoprotein A-II (ApoA-II) deficient (Apoa2(−/−)) and transgenic (Apoa2Tg) m...

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Pubblicato in:Sci Rep
Autori principali: Yang, Mu, Liu, Yingye, Dai, Jian, Li, Lin, Ding, Xin, Xu, Zhe, Mori, Masayuki, Miyahara, Hiroki, Sawashita, Jinko, Higuchi, Keiichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884826/
https://ncbi.nlm.nih.gov/pubmed/29618729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23755-y
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