The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma

The lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value...

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Publicado en:Oncotarget
Autores principales: Xavier-Magalhães, Ana, Gonçalves, Céline S., Fogli, Anne, Lourenço, Tatiana, Pojo, Marta, Pereira, Bruno, Rocha, Miguel, Lopes, Maria Celeste, Crespo, Inês, Rebelo, Olinda, Tão, Herminio, Lima, João, Moreira, Ricardo, Pinto, Afonso A., Jones, Chris, Reis, Rui M., Costello, Joseph F., Arnaud, Philippe, Sousa, Nuno, Costa, Bruno M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884661/
https://ncbi.nlm.nih.gov/pubmed/29644006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24597
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