PPAR-gamma activation is associated with reduced liver ischemia-reperfusion injury and altered tissue-resident macrophages polarization in a mouse model

BACKGROUND: PPAR-gamma (γ) is highly expressed in macrophages and its activation affects their polarization. The effect of PPAR-γ activation on Kupffer cells (KCs) and liver ischemia-reperfusion injury (IRI) has not yet been evaluated. We investigated the effect of PPAR-γ activation on KC-polarizati...

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Publicat a:PLoS One
Autors principals: Linares, Ivan, Farrokhi, Kaveh, Echeverri, Juan, Kaths, Johan Moritz, Kollmann, Dagmar, Hamar, Matyas, Urbanellis, Peter, Ganesh, Sujani, Adeyi, Oyedele A., Yip, Paul, Selzner, Markus, Selzner, Nazia
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884549/
https://ncbi.nlm.nih.gov/pubmed/29617419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195212
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