TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD

Amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) constitutes a devastating disease spectrum characterised by TDP-43 pathology. Understanding how TDP-43 contributes to neurodegeneration will help direct therapeutic efforts. Here, we have created a novel TDP-43 knock-in mouse with a hum...

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Publicado no:Nat Neurosci
Main Authors: White, Matthew A., Kim, Eosu, Duffy, Amanda, Adalbert, Robert, Phillips, Benjamin U., Peters, Owen M., Stephenson, Jodie, Yang, Sujeong, Massenzio, Francesca, Lin, Ziqiang, Andrews, Simon, Segonds-Pichon, Anne, Metterville, Jake, Saksida, Lisa M., Mead, Richard, Ribchester, Richard R, Barhomi, Youssef, Serre, Thomas, Coleman, Michael P., Fallon, Justin, Bussey, Timothy J., Brown, Robert H., Sreedharan, Jemeen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884423/
https://ncbi.nlm.nih.gov/pubmed/29556029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-018-0113-5
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