Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats

Heroin and oxycodone abuse occurs over a wide range of drug doses and by various routes of administration characterized by differing rates of drug absorption. The current study addressed the efficacy of a heroin vaccine [morphine hapten conjugated to keyhole limpet hemocyanin (M-KLH)] or oxycodone v...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Raleigh, Michael D., Laudenbach, Megan, Baruffaldi, Federico, Peterson, Samantha J., Roslawski, Michaela J., Birnbaum, Angela K., Carroll, F. Ivy, Runyon, Scott P., Winston, Scott, Pentel, Paul R., Pravetoni, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2018
Témata:
Drug Discovery and Translational Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884377/
https://ncbi.nlm.nih.gov/pubmed/29535156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.247049
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