The Proliferative Response to p27 Down-Regulation in Estrogen Plus Progestin Hormonal Therapy is Lost in Breast Tumors

Increased proliferation and breast cancer risk has been observed in postmenopausal women receiving estrogen (E) + progestin hormone replacement therapy (HRT). Progestin action is mediated through two progesterone receptor (PR) isoforms, PRA and PRB, with unique transcriptional activity and function....

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Aupperlee, Mark D., Kariagina, Anastasia, Zaremba, Nicole, Basson, Marc D., Schwartz, Richard C., Haslam, Sandra Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2018
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5884216/
https://ncbi.nlm.nih.gov/pubmed/29524829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.02.011
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