Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

BACKGROUND: The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1(+) MPCs is required for functional β cell generation. We have recently demonstrated the generatio...

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Bibliographic Details
Published in:Stem Cell Res Ther
Main Authors: Aigha, Idil I., Memon, Bushra, Elsayed, Ahmed K., Abdelalim, Essam M.
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883581/
https://ncbi.nlm.nih.gov/pubmed/29615106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-018-0834-0
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