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Low affinity uniporter carrier proteins can increase net substrate uptake rate by reducing efflux

Many organisms have several similar transporters with different affinities for the same substrate. Typically, high-affinity transporters are expressed when substrate is scarce and low-affinity ones when it is abundant. The benefit of using low instead of high-affinity transporters remains unclear, e...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Bosdriesz, Evert, Wortel, Meike T., Haanstra, Jurgen R., Wagner, Marijke J., de la Torre Cortés, Pilar, Teusink, Bas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5883050/
https://ncbi.nlm.nih.gov/pubmed/29615663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23528-7
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