α(2A)-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation

Cardiomyopathy is a common complication associated with increased mortality in sepsis, but lacks specific therapy. Here, using genetic and pharmacological approaches, we explored the therapeutic effect of α(2A)-adrenergic receptor (AR) blockade on septic cardiomyopathy. CLP-induced septic rats were...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yu, Xiaohui, Wang, Yuan, Yang, Duomeng, Tang, Xiangxu, Li, Hongmei, Lv, Xiuxiu, Qi, Renbin, Hu, Chaofeng, Lu, Daxiang, Lv, Ben, Wang, Huadong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882799/
https://ncbi.nlm.nih.gov/pubmed/29615637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23304-7
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