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Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum

Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associated with altered DS-dependent behavior. Giv...

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Udgivet i:Nat Commun
Main Authors: Muñoz, Braulio, Fritz, Brandon M., Yin, Fuqin, Atwood, Brady K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882774/
https://ncbi.nlm.nih.gov/pubmed/29615610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03683-1
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