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Serum Amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner

Serum amyloid A action in immune response and deposition in inflammation-linked amyloidosis involve SAA-lipid interactions. We show that SAA sequesters neutral and anionic phospholipids and their hydrolytic products to form nanoparticles, suggesting a synergy with phospholipase A(2). The lipid charg...

詳細記述

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書誌詳細
出版年:Chem Commun (Camb)
主要な著者: Jayaraman, Shobini, Gantz, Donald L., Haupt, Christian, Fändrich, Marcus, Gursky, Olga
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882536/
https://ncbi.nlm.nih.gov/pubmed/29565436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C8CC01424H
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