PDZ domain-binding motif of Tax sustains T-cell proliferation in HTLV-1-infected humanized mice

Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), an aggressive malignant proliferation of activated CD4+ T lymphocytes. The viral Tax oncoprotein is critically involved in both HTLV-1-replication and T-cell proliferation, a prerequisite t...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Pérès, Eléonore, Blin, Juliana, Ricci, Emiliano P., Artesi, Maria, Hahaut, Vincent, Van den Broeke, Anne, Corbin, Antoine, Gazzolo, Louis, Ratner, Lee, Jalinot, Pierre, Duc Dodon, Madeleine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882172/
https://ncbi.nlm.nih.gov/pubmed/29566098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006933
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