hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF-β signaling

GV1001 is a 16-amino acid peptide derived from the human telomerase reverse transcriptase (hTERT) protein (616–626; EARPALLTSRLRFIPK), which lies within the reverse transcriptase domain. Originally developed as an anticancer vaccine, GV1001 demonstrates diverse cellular effects, including anti-infla...

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Pubblicato in:Int J Mol Med
Autori principali: Chen, Wei, Shin, Ki-Hyuk, Kim, Sangjae, Shon, Won-Jun, Kim, Reuben H., Park, No-Hee, Kang, Mo K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881842/
https://ncbi.nlm.nih.gov/pubmed/29568955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3566
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