Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations

Protein O-fucosyltransferase-1 (POFUT1), which transfers fucose residues to acceptor sites on serine and threonine residues of epidermal growth factor-like repeats of recipient proteins, is essential for Notch signal transduction in mammals. Here, we examine the consequences of POFUT1 loss on the on...

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Vydáno v:Glycobiology
Hlavní autoři: McMillan, Brian J, Zimmerman, Brandon, Egan, Emily D, Lofgren, Michael, Xu, Xiang, Hesser, Anthony, Blacklow, Stephen C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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Original articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881682/
https://ncbi.nlm.nih.gov/pubmed/28334865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwx020
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