Genetic Mouse Models with Intestinal-Specific Tight Junction Deletion Resemble an Ulcerative Colitis Phenotype

BACKGROUND AND AIMS: A key pathogenetic feature of ulcerative colitis [UC] is an intrinsic low mucus phosphatidylcholine[PC] content. Recently, a paracellular transport for PC across tight junctions[TJs] was described, suggesting TJ disturbance as a cause of diminished luminal PC transport. Therefor...

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Dades bibliogràfiques
Publicat a:J Crohns Colitis
Autors principals: Stremmel, Wolfgang, Staffer, Simone, Schneider, Mathias Jochen, Gan-Schreier, Hongying, Wannhoff, Andreas, Stuhrmann, Nicole, Gauss, Annika, Wolburg, Hartwig, Mahringer, Anne, Swidsinski, Alexander, Efferth, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881657/
https://ncbi.nlm.nih.gov/pubmed/28575164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ecco-jcc/jjx075
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