MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss

Congenital cytomegalovirus (CMV) infection is the most common infectious cause of sensorineural hearing loss in children. While the importance of CMV-induced SNHL has been described, the mechanisms underlying its pathogenesis and the role of inflammatory responses remain elusive. The present study e...

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Veröffentlicht in:Int J Mol Med
Hauptverfasser: Zhuang, Wei, Wang, Caiji, Shi, Xi, Qiu, Shiwei, Zhang, Shili, Xu, Bing, Chen, Min, Jiang, Wen, Dong, Hongyan, Qiao, Yuehua
Format: Artigo
Sprache:Inglês
Veröffentlicht: D.A. Spandidos 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881649/
https://ncbi.nlm.nih.gov/pubmed/29512778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijmm.2018.3539
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