Phosphodiesterase-5 Inhibition Alleviates Pulmonary Hypertension and Basal Lamina Thickening in Rats Challenged by Chronic Hypoxia

Background: Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe pulmonary complications as pulmonary hypertension. Because nitric oxide (NO) is a critical mediator in the development of pulmonary hypertension, the modulators of its downstream function may become t...

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Publicado en:Front Physiol
Autores principales: Nydegger, Coline, Martinelli, Carla, Di Marco, Fabiano, Bulfamante, Gaetano, von Segesser, Ludwig, Tozzi, Piergiorgio, Samaja, Michele, Milano, Giuseppina
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880920/
https://ncbi.nlm.nih.gov/pubmed/29636700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00289
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