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Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients

BACKGROUND: The lysosomal enzyme α-L-Fucosidase-1 (FUCA-1) catalyzes the hydrolytic cleavage of terminal fucose residues. FUCA-1 gene is down-regulated in highly aggressive and metastatic human tumors as its inactivation perturbs the fucosylation of proteins involved in cell adhesion, migration and...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Bonin, Serena, Parascandolo, Alessia, Aversa, Cinzia, Barbazza, Renzo, Tsuchida, Nobuo, Castellone, Maria Domenica, Stanta, Giorgio, Vecchio, Giancarlo
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880599/
https://ncbi.nlm.nih.gov/pubmed/29632639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24445
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