Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients

BACKGROUND: The lysosomal enzyme α-L-Fucosidase-1 (FUCA-1) catalyzes the hydrolytic cleavage of terminal fucose residues. FUCA-1 gene is down-regulated in highly aggressive and metastatic human tumors as its inactivation perturbs the fucosylation of proteins involved in cell adhesion, migration and...

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Vydáno v:Oncotarget
Hlavní autoři: Bonin, Serena, Parascandolo, Alessia, Aversa, Cinzia, Barbazza, Renzo, Tsuchida, Nobuo, Castellone, Maria Domenica, Stanta, Giorgio, Vecchio, Giancarlo
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880599/
https://ncbi.nlm.nih.gov/pubmed/29632639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24445
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