Laboratory evaluation of the IFN-γ circuit for the molecular diagnosis of Mendelian susceptibility to mycobacterial disease

The integrity of the interferon (IFN)-γ circuit is necessary to mount an effective immune response to intra-macrophagic pathogens, especially Mycobacteria. Inherited monogenic defects in this circuit that disrupt the production of, or response to, IFN-γ underlie a primary immunodeficiency known as M...

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Publicat a:Crit Rev Clin Lab Sci
Autors principals: Esteve-Solé, Ana, Sologuren, Ithaisa, Martínez-Saavedra, María Teresa, Deyà-Martínez, Àngela, Oleaga-Quintas, Carmen, Martinez-Barricarte, Rubén, Martinez-Nalda, Andrea, Juan, Manel, Casanova, Jean-Laurent, Rodriguez-Gallego, Carlos, Alsina, Laia, Bustamante, Jacinta
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880527/
https://ncbi.nlm.nih.gov/pubmed/29502462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10408363.2018.1444580
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