An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage

Renewable tissues exhibit heightened sensitivity to DNA damage, which is thought to result from a high level of p53. However, cell proliferation in renewable tissues requires p53 down-regulation, creating an apparent discrepancy between the p53 level and elevated sensitivity to DNA damage. Using a c...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kuser-Abali, Gamze, Gong, Lu, Yan, Jiawei, Liu, Qingqing, Zeng, Weiqi, Williamson, Amanda, Lim, Chuan Bian, Molloy, Mary Ellen, Little, John B., Huang, Lei, Yuan, Zhi-Min
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879692/
https://ncbi.nlm.nih.gov/pubmed/29540569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719532115
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