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Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes

AIMS/HYPOTHESIS: Improved biomarkers are acutely needed for the detection of developing type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that elevated beta cell microRNA 21 (miR-21-5p) in rodent and human models of type 1 diabetes increased beta cell apoptosis. W...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Lakhter, Alexander J., Pratt, Rachel E., Moore, Rachel E., Doucette, Kaitlin K., Maier, Bernhard F., DiMeglio, Linda A., Sims, Emily K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878132/
https://ncbi.nlm.nih.gov/pubmed/29445851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4559-5
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