Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ

The retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ), are key regulators of helper T (Th)17 cell differentiation, which is involved in the innate immune system and autoimmune disorders. In this study, we investigated the effects of isoflavones on RORα/γ activity and the gene e...

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Publicat a:Toxicology
Autors principals: Kojima, Hiroyuki, Takeda, Yukimasa, Muromoto, Ryuta, Takahashi, Miki, Hirao, Toru, Takeuchi, Shinji, Jetten, Anton M., Matsuda, Tadashi
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877804/
https://ncbi.nlm.nih.gov/pubmed/25583575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.01.007
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