Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia

Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens. Functional polymorphisms exist in at least three genes that encode GSTs, including GSTM1, GS...

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Detalhes bibliográficos
Main Authors: Allan, James M., Wild, Christopher P., Rollinson, Sara, Willett, Eleanor V., Moorman, Anthony V., Dovey, Gareth J., Roddam, Philippa L., Roman, Eve, Cartwright, Raymond A., Morgan, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC58774/
https://ncbi.nlm.nih.gov/pubmed/11553769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191211198
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