Use of cilomilast-loaded phosphatiosomes to suppress neutrophilic inflammation for attenuating acute lung injury: the effect of nanovesicular surface charge

BACKGROUND: Cilomilast is a phosphodiesterase 4 (PDE4) inhibitor for treating inflammatory lung diseases. This agent has a narrow therapeutic index with significant adverse effects on the nervous system. This study was conducted to entrap cilomilast into PEGylated phosphatidylcholine-rich niosomes (...

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Vydáno v:J Nanobiotechnology
Hlavní autoři: Liu, Fu-Chao, Yu, Huang-Ping, Lin, Cheng-Yu, Elzoghby, Ahmed O., Hwang, Tsong-Long, Fang, Jia-You
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877390/
https://ncbi.nlm.nih.gov/pubmed/29602314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12951-018-0364-z
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