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The state of play in higher eukaryote gene annotation

A genome sequence is worthless if it cannot be deciphered, therefore efforts to describe — or ‘annotate’ — genes began as soon as DNA sequences became available. Whereas early work focused on individual protein-coding genes, the modern genomic ocean is a complex maelstrom of alternative splicing, no...

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Vydáno v:Nat Rev Genet
Hlavní autoři: Mudge, Jonathan M., Harrow, Jennifer
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876476/
https://ncbi.nlm.nih.gov/pubmed/27773922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg.2016.119
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