The Typhoid Toxin Produced by the Nontyphoidal Salmonella enterica Serotype Javiana Is Required for Induction of a DNA Damage Response In Vitro and Systemic Spread In Vivo

The Salmonella cytolethal distending toxin (S-CDT), first described as the “typhoid toxin” in Salmonella enterica subsp. enterica serotype Typhi, induces DNA damage in eukaryotic cells. Recent studies have shown that more than 40 nontyphoidal Salmonella (NTS) serotypes carry genes that encode S-CDT,...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Miller, Rachel A., Betteken, Michael I., Guo, Xiaodong, Altier, Craig, Duhamel, Gerald E., Wiedmann, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874915/
https://ncbi.nlm.nih.gov/pubmed/29588404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00467-18
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