CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders

OBJECTIVE: To test the association of antemortem CSF biomarkers with postmortem pathology in Lewy body disorders (LBD). METHODS: Patients with autopsy-confirmed LBD (n = 24) and autopsy-confirmed Alzheimer disease (AD) (n = 23) and cognitively normal (n = 36) controls were studied. In LBD, neuropath...

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Publicado no:Neurology
Main Authors: Irwin, David J., Xie, Sharon X., Coughlin, David, Nevler, Naomi, Akhtar, Rizwan S., McMillan, Corey T., Lee, Edward B., Wolk, David A., Weintraub, Daniel, Chen-Plotkin, Alice, Duda, John E., Spindler, Meredith, Siderowf, Andrew, Hurtig, Howard I., Shaw, Leslie M., Grossman, Murray, Trojanowski, John Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874449/
https://ncbi.nlm.nih.gov/pubmed/29467305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000005166
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