The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques

Apoptosis has been proposed as a key mechanism responsible for CD4(+) T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SIV-infected rhesus macaques (RMs). When administe...

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Vydáno v:J Clin Invest
Hlavní autoři: Laforge, Mireille, Silvestre, Ricardo, Rodrigues, Vasco, Garibal, Julie, Campillo-Gimenez, Laure, Mouhamad, Shahul, Monceaux, Valérie, Cumont, Marie-Christine, Rabezanahary, Henintsoa, Pruvost, Alain, Cordeiro-da-Silva, Anabela, Hurtrel, Bruno, Silvestri, Guido, Senik, Anna, Estaquier, Jérôme
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873886/
https://ncbi.nlm.nih.gov/pubmed/29553486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI95127
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