Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9

Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2), Huntington’s disease, and C9orf72-linked amyotrophic lateral sclerosis (C9-ALS). Means to target these repetitive RNAs are required for dia...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell
Egile Nagusiak: Batra, Ranjan, Nelles, David A., Pirie, Elaine, Blue, Steven M., Marina, Ryan J., Wang, Harrison, Chaim, Isaac A., Thomas, James D., Zhang, Nigel, Nguyen, Vu, Aigner, Stefan, Markmiller, Sebastian, Xia, Guangbin, Corbett, Kevin D., Swanson, Maurice S., Yeo, Gene W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873302/
https://ncbi.nlm.nih.gov/pubmed/28803727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.07.010
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