Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia

BACKGROUND: Diabetic nephropathy (DN) is the leading cause of renal failure, and podocyte dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH, encoded by Ephx2) is a conserved cytosolic enzyme whose inhibition has beneficial effects on renal function. The aim of this st...

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Published in:Biochim Biophys Acta
Main Authors: Bettaieb, Ahmed, Koike, Shinichiro, Hsu, Ming-Fo, Ito, Yoshihiro, Chahed, Samah, Bachaalany, Santana, Gruzdev, Artiom, Calvo-Rubio, Miguel, Lee, Kin Sing Stephen, Inceoglu, Bora, Imig, John D., Villalba, Jose M., Zeldin, Darryl C., Hammock, Bruce D., Haj, Fawaz G.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873293/
https://ncbi.nlm.nih.gov/pubmed/28757338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2017.07.021
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