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Clinical and functional impact of recurrent S1PR1 mutations in mantle cell lymphoma
S1PR1 mutations are present in 7.8% of patients with MCL and are significantly more frequent at relapse. S1PR1 mutations reduce expression of the S1PR1 receptor, which mediates migration towards the tissue-to-blood egress factor S1P in MCL. .
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873236/ https://ncbi.nlm.nih.gov/pubmed/29549086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017014860 |
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