MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease

Persistent activation of mitogen-activated protein kinase (MAPK) is believed to be involved in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in psoriasis development are largely unknown. In t...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Zhao, Weiheng, Xiao, Shuxiu, Li, Hongjin, Zheng, Tingting, Huang, Jian, Hu, Ran, Zhang, Baohua, Liu, Xinguang, Huang, Gonghua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873221/
https://ncbi.nlm.nih.gov/pubmed/29619028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00569
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