Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

BACKGROUND: Neuro–immune interaction underlies chronic neuroinflammation and aberrant sensory processing resulting in neuropathic pain. Despite the pathological significance of both neuroinflammation-driven peripheral sensitization and spinal sensitization, the functional relationship between these...

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Bibliographische Detailangaben
Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Kiguchi, Norikazu, Kobayashi, Daichi, Saika, Fumihiro, Matsuzaki, Shinsuke, Kishioka, Shiroh
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5872578/
https://ncbi.nlm.nih.gov/pubmed/29587798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1133-5
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