SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare RCC subtype that is caused by biallelic mutation of one of the four subunits of the SDH complex (SDHA, B, C, and D) and results in inactivation of the SDH enzyme. Here we describe a case of genetically characterized SDH-def...

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Detalhes bibliográficos
Publicado no:NPJ Precis Oncol
Main Authors: McEvoy, Christopher R., Koe, Lisa, Choong, David Y., Leong, Huei San, Xu, Huiling, Karikios, Deme, Plew, Jeffrey D., Prall, Owen W., Fellowes, Andrew P., Fox, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871886/
https://ncbi.nlm.nih.gov/pubmed/29872718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41698-018-0053-2
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