A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

The hemagglutinin (HA) receptor-binding site (RBS) in human influenza A viruses is critical for attachment to host cells, which imposes a functional constraint on its natural evolution. On the other hand, being part of the major antigenic sites, the HA RBS of human H3N2 viruses needs to constantly m...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Wu, Nicholas C., Thompson, Andrew J., Xie, Jia, Lin, Chih-Wei, Nycholat, Corwin M., Zhu, Xueyong, Lerner, Richard A., Paulson, James C., Wilson, Ian A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871881/
https://ncbi.nlm.nih.gov/pubmed/29593268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03663-5
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