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A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site
The hemagglutinin (HA) receptor-binding site (RBS) in human influenza A viruses is critical for attachment to host cells, which imposes a functional constraint on its natural evolution. On the other hand, being part of the major antigenic sites, the HA RBS of human H3N2 viruses needs to constantly m...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5871881/ https://ncbi.nlm.nih.gov/pubmed/29593268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03663-5 |
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