Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

Restoring adult stem cell function provides an exciting approach for rejuvenating the aging brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive. Here we report that the enzyme ten eleven translocation methylcytosine dioxygenase 2 (Tet2), which catalyzes the producti...

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Udgivet i:Cell Rep
Main Authors: Gontier, Geraldine, Iyer, Manasi, Shea, Jeremy M., Bieri, Gregor, Wheatley, Elizabeth G., Ramalho-Santos, Miguel, Villeda, Saul A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870899/
https://ncbi.nlm.nih.gov/pubmed/29466726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.001
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