The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors

Cardiac stem/progenitor cells hold great potential for regenerative therapies; however, the mechanisms regulating their expansion and differentiation remain insufficiently defined. Here we show that Ldb1 is a central regulator of genome organization in cardiac progenitor cells, which is crucial for...

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Publié dans:Cell Stem Cell
Auteurs principaux: Caputo, Luca, Witzel, Hagen R., Kolovos, Petros, Cheedipudi, Sirisha, Looso, Mario, Mylona, Athina, van IJcken, Wilfred F.J., Laugwitz, Karl-Ludwig, Evans, Sylvia M., Braun, Thomas, Soler, Eric, Grosveld, Frank, Dobreva, Gergana
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870759/
https://ncbi.nlm.nih.gov/pubmed/26321200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2015.08.007
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