Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage

BACKGROUND: This study aimed to investigate the potential neuroprotective effect of recombinant osteopontin (r-OPN) on apoptotic changes via modulating phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK-3β) signaling in a rat model of intracerebral hemorrhage (ICH). MATERIAL...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Zhang, Wenqian, Cui, Ying, Gao, Junling, Li, Ran, Jiang, Xiaohua, Tian, Yanxia, Wang, Kaijie, Cui, Jianzhong
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2018
Assuntos:
Animal Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870133/
https://ncbi.nlm.nih.gov/pubmed/29550832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.905700
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