Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells

Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y(+)L for cationic amino acid transport. The pathogenesis of LPI is still unknown. In this study, we have utilized a gene silencing approach in m...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rotoli, Bianca Maria, Barilli, Amelia, Visigalli, Rossana, Ingoglia, Filippo, Milioli, Marco, Di Lascia, Maria, Riccardi, Benedetta, Puccini, Paola, Dall’Asta, Valeria
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868322/
https://ncbi.nlm.nih.gov/pubmed/29616026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00508
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