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Macrophage overexpression of matrix metalloproteinase-9 in aged mice improves diastolic physiology and cardiac wound healing after myocardial infarction

Matrix metalloproteinase (MMP)-9 increases in the myocardium with advanced age and after myocardial infarction (MI). Because young transgenic (TG) mice overexpressing human MMP-9 only in macrophages show better outcomes post-MI, whereas aged TG mice show a worse aging phenotype, we wanted to evaluat...

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Bibliografski detalji
Izdano u:Am J Physiol Heart Circ Physiol
Glavni autori: Meschiari, Cesar A., Jung, Mira, Iyer, Rugmani Padmanabhan, Yabluchanskiy, Andriy, Toba, Hiroe, Garrett, Michael R., Lindsey, Merry L.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2018
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867652/
https://ncbi.nlm.nih.gov/pubmed/29030341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00453.2017
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