Specific Expression of PD-L1 in RELA-Fusion Supratentorial Ependymoma: Implications for PD-1 Targeted Therapy

BACKGROUND: A desperate need for novel therapies in pediatric ependymoma (EPN) exists, as chemotherapy remains ineffective and radiotherapy often fails. EPN have significant infiltration of immune cells, which correlates with outcome. Immune checkpoint inhibitors provide an avenue for new treatments...

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Pubblicato in:Pediatr Blood Cancer
Autori principali: Witt, Davis A., Donson, Andrew M., Amani, Vladimir, Moreira, Daniel C., Sanford, Bridget, Hoffman, Lindsey M., Handler, Michael H., Mulcahy Levy, Jean M., Jones, Kenneth L., Nellan, Anandani, Foreman, Nicholas K., Griesinger, Andrea M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867234/
https://ncbi.nlm.nih.gov/pubmed/29350470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.26960
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