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Norcantharidin, a clinical used chemotherapeutic agent, acts as a powerful inhibitor by interfering with fibrinogen–integrin α(II) (b)β(3) binding in human platelets

During platelet activation, fibrinogen binds to its specific platelet receptor, integrin α(II) (b)β(3), thus completing the final common pathway for platelet aggregation. Norcantharidin (NCTD) is a promising anticancer agent in China from medicinal insect blister beetle. In this study, we provided t...

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Библиографические подробности
Опубликовано в: :J Cell Mol Med
Главные авторы: Hsia, Chih‐Hsuan, Lu, Wan‐Jung, Lin, Kuan‐Hung, Chou, Duen‐Suey, Geraldine, Pitchairaj, Jayakuma, Thanasekaran, Chang, Nen‐Chung, Sheu, Joen‐Rong
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5867116/
https://ncbi.nlm.nih.gov/pubmed/29369482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13488
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