Patterns of shared signatures of recent positive selection across human populations
Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population...
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Publicado no: | Nat Ecol Evol |
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2018
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5866773/ https://ncbi.nlm.nih.gov/pubmed/29459708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-018-0478-6 |
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pubmed-58667732018-08-19 Patterns of shared signatures of recent positive selection across human populations Johnson, Kelsey Elizabeth Voight, Benjamin F. Nat Ecol Evol Article Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population and the selective pressure could be common across populations and environments. Identifying such shared selective events could identify genomic loci and human traits important in recent history across the globe. Additionally, genomic annotations that recently became available could help attach these signatures to a potential gene and molecular phenotype selected across populations. Here, we present a catalog of selective sweeps in humans, and identify those that overlap and share a sweeping haplotype. We connect these sweep overlaps with potential biological mechanisms at several loci, including potential new sites of adaptive introgression, the glycophorin locus associated with malarial resistance, and the alcohol dehydrogenase cluster associated with alcohol dependency. 2018-02-19 2018-04 /pmc/articles/PMC5866773/ /pubmed/29459708 http://dx.doi.org/10.1038/s41559-018-0478-6 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
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Article Johnson, Kelsey Elizabeth Voight, Benjamin F. Patterns of shared signatures of recent positive selection across human populations |
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Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population and the selective pressure could be common across populations and environments. Identifying such shared selective events could identify genomic loci and human traits important in recent history across the globe. Additionally, genomic annotations that recently became available could help attach these signatures to a potential gene and molecular phenotype selected across populations. Here, we present a catalog of selective sweeps in humans, and identify those that overlap and share a sweeping haplotype. We connect these sweep overlaps with potential biological mechanisms at several loci, including potential new sites of adaptive introgression, the glycophorin locus associated with malarial resistance, and the alcohol dehydrogenase cluster associated with alcohol dependency. |
author |
Johnson, Kelsey Elizabeth Voight, Benjamin F. |
author_facet |
Johnson, Kelsey Elizabeth Voight, Benjamin F. |
author_sort |
Johnson, Kelsey Elizabeth |
title |
Patterns of shared signatures of recent positive selection across human populations |
title_short |
Patterns of shared signatures of recent positive selection across human populations |
title_full |
Patterns of shared signatures of recent positive selection across human populations |
title_fullStr |
Patterns of shared signatures of recent positive selection across human populations |
title_full_unstemmed |
Patterns of shared signatures of recent positive selection across human populations |
title_sort |
patterns of shared signatures of recent positive selection across human populations |
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Nat Ecol Evol |
publishDate |
2018 |
url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC5866773/ https://ncbi.nlm.nih.gov/pubmed/29459708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-018-0478-6 |
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1820961094216187904 |