Patterns of shared signatures of recent positive selection across human populations

Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population...

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Publicado no:Nat Ecol Evol
Main Authors: Johnson, Kelsey Elizabeth, Voight, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866773/
https://ncbi.nlm.nih.gov/pubmed/29459708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-018-0478-6
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spelling pubmed-58667732018-08-19 Patterns of shared signatures of recent positive selection across human populations Johnson, Kelsey Elizabeth Voight, Benjamin F. Nat Ecol Evol Article Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population and the selective pressure could be common across populations and environments. Identifying such shared selective events could identify genomic loci and human traits important in recent history across the globe. Additionally, genomic annotations that recently became available could help attach these signatures to a potential gene and molecular phenotype selected across populations. Here, we present a catalog of selective sweeps in humans, and identify those that overlap and share a sweeping haplotype. We connect these sweep overlaps with potential biological mechanisms at several loci, including potential new sites of adaptive introgression, the glycophorin locus associated with malarial resistance, and the alcohol dehydrogenase cluster associated with alcohol dependency. 2018-02-19 2018-04 /pmc/articles/PMC5866773/ /pubmed/29459708 http://dx.doi.org/10.1038/s41559-018-0478-6 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Johnson, Kelsey Elizabeth
Voight, Benjamin F.
Patterns of shared signatures of recent positive selection across human populations
description Signatures of recent positive selection often overlap across human populations, but the question of how often these overlaps represent a single ancestral event remains unresolved. If a single selective event spread across many populations, the same sweeping haplotype should appear in each population and the selective pressure could be common across populations and environments. Identifying such shared selective events could identify genomic loci and human traits important in recent history across the globe. Additionally, genomic annotations that recently became available could help attach these signatures to a potential gene and molecular phenotype selected across populations. Here, we present a catalog of selective sweeps in humans, and identify those that overlap and share a sweeping haplotype. We connect these sweep overlaps with potential biological mechanisms at several loci, including potential new sites of adaptive introgression, the glycophorin locus associated with malarial resistance, and the alcohol dehydrogenase cluster associated with alcohol dependency.
author Johnson, Kelsey Elizabeth
Voight, Benjamin F.
author_facet Johnson, Kelsey Elizabeth
Voight, Benjamin F.
author_sort Johnson, Kelsey Elizabeth
title Patterns of shared signatures of recent positive selection across human populations
title_short Patterns of shared signatures of recent positive selection across human populations
title_full Patterns of shared signatures of recent positive selection across human populations
title_fullStr Patterns of shared signatures of recent positive selection across human populations
title_full_unstemmed Patterns of shared signatures of recent positive selection across human populations
title_sort patterns of shared signatures of recent positive selection across human populations
container_title Nat Ecol Evol
publishDate 2018
url https://ncbi.nlm.nih.gov/pmc/articles/PMC5866773/
https://ncbi.nlm.nih.gov/pubmed/29459708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-018-0478-6
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