HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia

BACKGROUND: Diarrhea is a severe complication in HIV-1-infected patients with Trans-activator of transcription (HIV-1 Tat) protein being recognized as a major underlying cause. Beside its direct enterotoxic effects, Tat protein has been recently shown to affect enteric glial cell (EGC) activity. EGC...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Sarnelli, Giovanni, Seguella, Luisa, Pesce, Marcella, Lu, Jie, Gigli, Stefano, Bruzzese, Eugenia, Lattanzi, Roberta, D’Alessandro, Alessandra, Cuomo, Rosario, Steardo, Luca, Esposito, Giuseppe
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866515/
https://ncbi.nlm.nih.gov/pubmed/29573741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1126-4
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