PPARα agonist fenofibrate enhances fatty acid β-oxidation and attenuates polycystic kidney and liver disease in mice

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that promotes fatty acid β-oxidation (FAO) and oxidative phosphorylation (OXPHOS). We and others have recently shown that PPARα and its target genes are downregulated, and FAO and OXPHOS are impaired in autosomal domi...

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Bibliografske podrobnosti
izdano v:Am J Physiol Renal Physiol
Main Authors: Lakhia, Ronak, Yheskel, Matanel, Flaten, Andrea, Quittner-Strom, Ezekiel B., Holland, William L., Patel, Vishal
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866355/
https://ncbi.nlm.nih.gov/pubmed/28903946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00352.2017
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