Combined Angiotensin Receptor–Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure

BACKGROUND: There is a paucity of data about the mechanisms by which sacubitril/valsartan (also known as LCZ696) improves outcomes in patients with heart failure. Specifically, the effects of sacubitril/valsartan on vascular function and NO bioavailability have not been investigated. We hypothesized...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Trivedi, Rishi K., Polhemus, David J., Li, Zhen, Yoo, Daniel, Koiwaya, Hiroshi, Scarborough, Amy, Goodchild, Traci T., Lefer, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5866338/
https://ncbi.nlm.nih.gov/pubmed/29502102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.008268
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