Evaluation of type 2 diabetic mellitus animal models via interactions between insulin and mitogen-activated protein kinase signaling pathways induced by a high fat and sugar diet and streptozotocin

Type 2 diabetic mellitus (T2DM), which is characterized by insulin resistance (IR), hyperglycemia and hyperlipidemia, is a comprehensive dysfunction of metabolism. The insulin receptor (INSR)/phosphoinositide 3-kinase (PI3K)/AKT signaling pathway is well acknowledged as a predominant pathway associa...

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Pubblicato in:Mol Med Rep
Autori principali: Zhuo, Juncheng, Zeng, Qiaohuang, Cai, Dake, Zeng, Xiaohui, Chen, Yuxing, Gan, Haining, Huang, Xuejun, Yao, Nan, Huang, Dane, Zhang, Chengzhe
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865978/
https://ncbi.nlm.nih.gov/pubmed/29393432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.8504
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